Drug interactions
Cinnarizine + Imipramine
Severity: Moderate
Cinnarizine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine with calcium channel blocking activity, and combining it with imipramine can intensify drowsiness and impair alertness. Additive anticholinergic effects and, rarely, extrapyramidal symptoms or hypotension may also occur.
What this interaction means in plain words
Cinnarizine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and antimuscarinic effects through pharmacodynamic synergy.
What to do
Monitor for sedation, dizziness and anticholinergic symptoms, and use the lowest effective doses. Warn patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Imipramine?
MediHelp rates the interaction as moderate. Cinnarizine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine with calcium channel blocking activity, and combining it with imipramine can intensify drowsiness and impair alertness. Additive anticholinergic effects and, rarely, extrapyramidal symptoms or hypotension may also occur.
How serious is the interaction between Cinnarizine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and anticholinergic symptoms, and use the lowest effective doses. Warn patients about driving and operating machinery.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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