Drug interactions
Cinnarizine + Oxazepam
Severity: Moderate
Cinnarizine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness. With oxazepam, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Cinnarizine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A enhancement and central H1 antagonism.
What to do
Use the lowest effective doses and warn the patient about drowsiness when driving or operating machinery. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Oxazepam?
MediHelp rates the interaction as moderate. Cinnarizine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness. With oxazepam, sedation and psychomotor impairment may be increased.
How serious is the interaction between Cinnarizine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about drowsiness when driving or operating machinery. Reduce the dose if excessive sedation occurs.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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