Drug interactions
Ciprofibrate + Colchicine
Severity: Major
Ciprofibrate and Colchicine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both colchicine and fibrates can cause myopathy, and combined use has been associated with rhabdomyolysis. The risk is higher with renal impairment and in older patients.
What this interaction means in plain words
Ciprofibrate and Colchicine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive myotoxicity from two drugs that can independently cause muscle injury.
What to do
Avoid the combination where possible. If used, monitor for muscle pain, weakness and dark urine, check creatine kinase, and stop if myopathy develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Ciprofibrate with Colchicine?
MediHelp rates the interaction as major. Ciprofibrate and Colchicine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both colchicine and fibrates can cause myopathy, and combined use has been associated with rhabdomyolysis. The risk is higher with renal impairment and in older patients.
How serious is the interaction between Ciprofibrate and Colchicine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor for muscle pain, weakness and dark urine, check creatine kinase, and stop if myopathy develops.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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