Drug interactions
Ciprofloxacin + Dapagliflozin-metformin
Severity: Moderate
Ciprofloxacin and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. Severe dysglycemia has been reported, especially in older patients and those with renal impairment.
What this interaction means in plain words
Ciprofloxacin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic insulin release, causing unpredictable glucose changes that add to antidiabetic effects.
What to do
Monitor blood glucose closely during ciprofloxacin therapy and teach patients to recognize symptoms of dysglycemia. Choose a different antibiotic class if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. Severe dysglycemia has been reported, especially in older patients and those with renal impairment.
How serious is the interaction between Ciprofloxacin and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during ciprofloxacin therapy and teach patients to recognize symptoms of dysglycemia. Choose a different antibiotic class if glucose becomes unstable.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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