Drug interactions
Ciprofloxacin + Doxepin
Severity: Moderate
Ciprofloxacin and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, can prolong the QT interval, and ciprofloxacin has a small additive effect. Risk is greater with overdose, structural heart disease or electrolyte abnormalities.
What this interaction means in plain words
Ciprofloxacin and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation from cardiac ion channel blockade.
What to do
Check ECG in patients with cardiac risk factors and correct hypokalemia and hypomagnesemia. Avoid combining with further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Doxepin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, can prolong the QT interval, and ciprofloxacin has a small additive effect. Risk is greater with overdose, structural heart disease or electrolyte abnormalities.
How serious is the interaction between Ciprofloxacin and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG in patients with cardiac risk factors and correct hypokalemia and hypomagnesemia. Avoid combining with further QT-prolonging drugs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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