Drug interactions
Ciprofloxacin + Histrelin
Severity: Moderate
Ciprofloxacin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval. Ciprofloxacin also has QT liability, so combined use may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Ciprofloxacin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with GnRH agonist-induced hypogonadism altering cardiac repolarisation.
What to do
Review ECG and electrolytes in patients with cardiac risk factors before combining. Choose an antibiotic with less QT effect if the baseline QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Ciprofloxacin with Histrelin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval. Ciprofloxacin also has QT liability, so combined use may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Ciprofloxacin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and electrolytes in patients with cardiac risk factors before combining. Choose an antibiotic with less QT effect if the baseline QTc is prolonged.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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