Drug interactions
Ciprofloxacin + Isavuconazonium
Severity: Minor
Ciprofloxacin and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a weak CYP3A4 inhibitor and could slightly raise isavuconazole concentrations, the active moiety. Both drugs may also affect the QT interval, though isavuconazole tends to shorten it.
What this interaction means in plain words
Ciprofloxacin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of isavuconazole by ciprofloxacin.
What to do
No routine dose adjustment is needed. Monitor for isavuconazole adverse effects such as liver enzyme elevation or gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Isavuconazonium?
MediHelp rates the interaction as minor. Ciprofloxacin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin is a weak CYP3A4 inhibitor and could slightly raise isavuconazole concentrations, the active moiety. Both drugs may also affect the QT interval, though isavuconazole tends to shorten it.
How serious is the interaction between Ciprofloxacin and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for isavuconazole adverse effects such as liver enzyme elevation or gastrointestinal symptoms.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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