Drug interactions
Ciprofloxacin + Ketoprofen
Severity: Moderate
Ciprofloxacin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and seizures, particularly at high doses or in patients with epilepsy or prior seizures. The absolute risk is low.
What this interaction means in plain words
Ciprofloxacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ketoprofen belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs; the exact mechanism is not fully established.
What to do
Avoid the combination in patients with seizure history or other seizure risk factors; otherwise watch for tremor, agitation or seizures and stop ciprofloxacin if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Ketoprofen?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and seizures, particularly at high doses or in patients with epilepsy or prior seizures. The absolute risk is low.
How serious is the interaction between Ciprofloxacin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or other seizure risk factors; otherwise watch for tremor, agitation or seizures and stop ciprofloxacin if they occur.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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