Drug interactions
Ciprofloxacin + Lemborexant
Severity: Moderate
Ciprofloxacin and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This can cause next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Ciprofloxacin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by ciprofloxacin reduces the clearance of lemborexant.
What to do
Limit lemborexant to the lower maximum nightly dose recommended with weak CYP3A4 inhibitors. Counsel the patient about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Ciprofloxacin with Lemborexant?
MediHelp rates the interaction as moderate. Ciprofloxacin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This can cause next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Ciprofloxacin and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower maximum nightly dose recommended with weak CYP3A4 inhibitors. Counsel the patient about next-day drowsiness.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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