Drug interactions
Ciprofloxacin + Mexiletine
Severity: Moderate
Ciprofloxacin and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is cleared partly by CYP1A2, and ciprofloxacin inhibits this enzyme. Mexiletine levels may rise, increasing neurological effects such as tremor, dizziness and nausea, and the risk of arrhythmia.
What this interaction means in plain words
Ciprofloxacin and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Mexiletine belongs to Cardiovascular.
Why it happens
Ciprofloxacin inhibits CYP1A2, reducing mexiletine metabolic clearance.
What to do
Monitor for signs of mexiletine toxicity and consider a dose reduction, and monitor serum levels where available. Obtain an ECG if arrhythmia is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Ciprofloxacin with Mexiletine?
MediHelp rates the interaction as moderate. Ciprofloxacin and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mexiletine is cleared partly by CYP1A2, and ciprofloxacin inhibits this enzyme. Mexiletine levels may rise, increasing neurological effects such as tremor, dizziness and nausea, and the risk of arrhythmia.
How serious is the interaction between Ciprofloxacin and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of mexiletine toxicity and consider a dose reduction, and monitor serum levels where available. Obtain an ECG if arrhythmia is a concern.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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