Drug interactions
Ciprofloxacin + Mifepristone
Severity: Moderate
Ciprofloxacin and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can prolong the QT interval and ciprofloxacin also carries QT risk, so combined use may increase arrhythmia risk. Ciprofloxacin is a weak CYP3A4 inhibitor and may modestly raise mifepristone exposure.
What this interaction means in plain words
Ciprofloxacin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by ciprofloxacin raising mifepristone levels.
What to do
Use an alternative antibiotic when mifepristone is given at doses associated with QT effects, particularly in patients with cardiac risk factors. Obtain an ECG and correct electrolytes if the combination is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Mifepristone?
MediHelp rates the interaction as moderate. Ciprofloxacin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can prolong the QT interval and ciprofloxacin also carries QT risk, so combined use may increase arrhythmia risk. Ciprofloxacin is a weak CYP3A4 inhibitor and may modestly raise mifepristone exposure.
How serious is the interaction between Ciprofloxacin and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when mifepristone is given at doses associated with QT effects, particularly in patients with cardiac risk factors. Obtain an ECG and correct electrolytes if the combination is necessary.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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