Drug interactions
Ciprofloxacin + Nebivolol
Severity: Minor
Ciprofloxacin and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a CYP1A2 inhibitor with little effect on CYP2D6, so a clinically important rise in nebivolol levels is unlikely. Any effect would be additive bradycardia or hypotension in susceptible patients.
What this interaction means in plain words
Ciprofloxacin and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Nebivolol belongs to Cardiovascular.
Why it happens
Theoretical weak inhibition of CYP2D6-mediated nebivolol metabolism; not well established.
What to do
No dose adjustment is usually required; monitor heart rate and blood pressure when starting ciprofloxacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Ciprofloxacin with Nebivolol?
MediHelp rates the interaction as minor. Ciprofloxacin and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin is a CYP1A2 inhibitor with little effect on CYP2D6, so a clinically important rise in nebivolol levels is unlikely. Any effect would be additive bradycardia or hypotension in susceptible patients.
How serious is the interaction between Ciprofloxacin and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor heart rate and blood pressure when starting ciprofloxacin.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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