Drug interactions
Ciprofloxacin + Oxaprozin
Severity: Moderate
Ciprofloxacin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with ciprofloxacin may increase the risk of CNS stimulation and seizures. The absolute risk is low but higher in patients with epilepsy, CNS disease, renal impairment or high fluoroquinolone doses.
What this interaction means in plain words
Ciprofloxacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Oxaprozin belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptors, and NSAIDs may potentiate this effect; the mechanism is not fully established.
What to do
Avoid in patients with seizure disorders or a lowered seizure threshold, and consider an alternative antibiotic. Adjust ciprofloxacin dose for renal function and monitor for neurologic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Oxaprozin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with ciprofloxacin may increase the risk of CNS stimulation and seizures. The absolute risk is low but higher in patients with epilepsy, CNS disease, renal impairment or high fluoroquinolone doses.
How serious is the interaction between Ciprofloxacin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or a lowered seizure threshold, and consider an alternative antibiotic. Adjust ciprofloxacin dose for renal function and monitor for neurologic symptoms.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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