Drug interactions
Ciprofloxacin + Probenecid
Severity: Minor
Ciprofloxacin and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal tubular secretion of ciprofloxacin, raising its serum concentrations. This may increase the risk of dose-related adverse effects, particularly in renal impairment.
What this interaction means in plain words
Ciprofloxacin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular transporters that secrete ciprofloxacin, decreasing its clearance.
What to do
Dose changes are not usually needed. Monitor for CNS effects and tendon symptoms in patients with renal dysfunction or advanced age.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Probenecid?
MediHelp rates the interaction as minor. Ciprofloxacin and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces the renal tubular secretion of ciprofloxacin, raising its serum concentrations. This may increase the risk of dose-related adverse effects, particularly in renal impairment.
How serious is the interaction between Ciprofloxacin and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose changes are not usually needed. Monitor for CNS effects and tendon symptoms in patients with renal dysfunction or advanced age.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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