Drug interactions
Ciprofloxacin + Quetiapine
Severity: Moderate
Ciprofloxacin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin and quetiapine each have the potential to lengthen the QT interval, and together they may increase the likelihood of torsades de pointes. Patients with bradycardia, electrolyte abnormalities, structural heart disease or a congenital long QT syndrome are most at risk.
What this interaction means in plain words
Ciprofloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive hERG potassium channel inhibition causing delayed cardiac repolarization.
What to do
Check ECG and electrolytes before starting, and correct potassium and magnesium abnormalities. Consider a non-fluoroquinolone antibiotic in patients with additional QT risk factors, or monitor the QTc closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Ciprofloxacin with Quetiapine?
MediHelp rates the interaction as moderate. Ciprofloxacin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin and quetiapine each have the potential to lengthen the QT interval, and together they may increase the likelihood of torsades de pointes. Patients with bradycardia, electrolyte abnormalities, structural heart disease or a congenital long QT syndrome are most at risk.
How serious is the interaction between Ciprofloxacin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before starting, and correct potassium and magnesium abnormalities. Consider a non-fluoroquinolone antibiotic in patients with additional QT risk factors, or monitor the QTc closely.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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