Drug interactions
Ciprofloxacin + Sulindac
Severity: Moderate
Ciprofloxacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin can lower the seizure threshold and NSAIDs may add to this effect. Seizures are rare but more likely with high doses, renal impairment or underlying CNS disease.
What this interaction means in plain words
Ciprofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptor binding, possibly potentiated by NSAIDs; the exact mechanism is not established.
What to do
Avoid in patients with epilepsy or other seizure risk factors and adjust ciprofloxacin dose to renal function. Stop ciprofloxacin if CNS excitation or seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Sulindac?
MediHelp rates the interaction as moderate. Ciprofloxacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin can lower the seizure threshold and NSAIDs may add to this effect. Seizures are rare but more likely with high doses, renal impairment or underlying CNS disease.
How serious is the interaction between Ciprofloxacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or other seizure risk factors and adjust ciprofloxacin dose to renal function. Stop ciprofloxacin if CNS excitation or seizures occur.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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