Drug interactions
Ciprofloxacin + Terbinafine
Severity: Minor
Ciprofloxacin and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy mechanism is questionable, since terbinafine is cleared by multiple CYP enzymes and ciprofloxacin is not known to cause a meaningful rise in terbinafine exposure. No well-documented clinically significant interaction exists.
What this interaction means in plain words
Ciprofloxacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Terbinafine belongs to Anti Fungals.
Why it happens
Mechanism not established; a minor CYP1A2 effect is theoretical.
What to do
No routine action is needed beyond awareness. Monitor for terbinafine adverse effects such as gastrointestinal upset or liver test changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciprofloxacin and Terbinafine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Ciprofloxacin with Terbinafine?
MediHelp rates the interaction as minor. Ciprofloxacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy mechanism is questionable, since terbinafine is cleared by multiple CYP enzymes and ciprofloxacin is not known to cause a meaningful rise in terbinafine exposure. No well-documented clinically significant interaction exists.
How serious is the interaction between Ciprofloxacin and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond awareness. Monitor for terbinafine adverse effects such as gastrointestinal upset or liver test changes.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
