Drug interactions
Ciprofloxacin + Tolazamide
Severity: Moderate
Ciprofloxacin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause severe hypoglycemia in patients taking sulfonylureas. Ciprofloxacin may unpredictably lower or raise glucose and potentiate the effect of tolazamide.
What this interaction means in plain words
Ciprofloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Tolazamide belongs to Endocrine.
Why it happens
Additive stimulation of insulin release; the fluoroquinolone effect is on pancreatic beta cells.
What to do
Monitor blood glucose closely during ciprofloxacin treatment and educate the patient about hypoglycemia. Reduce the sulfonylurea dose if low glucose occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ciprofloxacin with Tolazamide?
MediHelp rates the interaction as moderate. Ciprofloxacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause severe hypoglycemia in patients taking sulfonylureas. Ciprofloxacin may unpredictably lower or raise glucose and potentiate the effect of tolazamide.
How serious is the interaction between Ciprofloxacin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during ciprofloxacin treatment and educate the patient about hypoglycemia. Reduce the sulfonylurea dose if low glucose occurs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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