Drug interactions
Ciprofloxacin + Trilaciclib
Severity: Minor
Ciprofloxacin and Trilaciclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which contribute to the renal handling of some drugs. Ciprofloxacin is partly secreted by renal transporters, so its levels might rise slightly, but this is not clinically established.
What this interaction means in plain words
Ciprofloxacin and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Trilaciclib belongs to Oncology.
Why it happens
Possible reduced renal tubular secretion of ciprofloxacin through MATE/OCT2 inhibition.
What to do
No routine change is needed; monitor for ciprofloxacin adverse effects, especially in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Ciprofloxacin with Trilaciclib?
MediHelp rates the interaction as minor. Ciprofloxacin and Trilaciclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which contribute to the renal handling of some drugs. Ciprofloxacin is partly secreted by renal transporters, so its levels might rise slightly, but this is not clinically established.
How serious is the interaction between Ciprofloxacin and Trilaciclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for ciprofloxacin adverse effects, especially in patients with renal impairment.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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