Drug interactions
Ciprofloxacin + Umeclidinium-vilanterol
Severity: Moderate
Ciprofloxacin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin can prolong the QT interval, and vilanterol, a long-acting beta-agonist, may add to cardiac effects such as tachycardia and repolarization changes. Together they may raise the risk of ventricular arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Ciprofloxacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation and beta-adrenergic cardiac stimulation.
What to do
Check baseline ECG and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Monitor for palpitations or syncope, and consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ciprofloxacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin can prolong the QT interval, and vilanterol, a long-acting beta-agonist, may add to cardiac effects such as tachycardia and repolarization changes. Together they may raise the risk of ventricular arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Ciprofloxacin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Monitor for palpitations or syncope, and consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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