Drug interactions
Ciprofloxacin + Venetoclax
Severity: Moderate
Ciprofloxacin and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may inhibit CYP3A and raise venetoclax exposure, increasing the risk of neutropenia and tumor lysis syndrome. The effect is modest compared with strong inhibitors.
What this interaction means in plain words
Ciprofloxacin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated venetoclax metabolism.
What to do
Reduce the venetoclax dose by at least 50% if a moderate CYP3A inhibitor is required, and monitor blood counts and tumor lysis signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Ciprofloxacin with Venetoclax?
MediHelp rates the interaction as moderate. Ciprofloxacin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin may inhibit CYP3A and raise venetoclax exposure, increasing the risk of neutropenia and tumor lysis syndrome. The effect is modest compared with strong inhibitors.
How serious is the interaction between Ciprofloxacin and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the venetoclax dose by at least 50% if a moderate CYP3A inhibitor is required, and monitor blood counts and tumor lysis signs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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