Drug interactions
Ciprofloxacin + Voclosporin
Severity: Moderate
Ciprofloxacin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposure, and ciprofloxacin has a modest QT effect. Concurrent use may add to arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Ciprofloxacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes in patients with other QT risk factors. Choose a non-QT-prolonging antibiotic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Voclosporin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic exposure, and ciprofloxacin has a modest QT effect. Concurrent use may add to arrhythmia risk in vulnerable patients.
How serious is the interaction between Ciprofloxacin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with other QT risk factors. Choose a non-QT-prolonging antibiotic if the QTc is prolonged.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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