Drug interactions
Cisatracurium + Doxepin
Severity: Minor
Cisatracurium and Doxepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic activity, but a clinically meaningful interaction with cisatracurium is not well documented. Any effect on neuromuscular blockade is expected to be small.
What this interaction means in plain words
Cisatracurium and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Theoretical additive antimuscarinic effects; cisatracurium itself has no meaningful antimuscarinic action, so no established mechanism.
What to do
No specific action is needed beyond routine train-of-four monitoring during anesthesia. Watch for anticholinergic effects such as tachycardia or urinary retention postoperatively.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Cisatracurium with Doxepin?
MediHelp rates the interaction as minor. Cisatracurium and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin has anticholinergic activity, but a clinically meaningful interaction with cisatracurium is not well documented. Any effect on neuromuscular blockade is expected to be small.
How serious is the interaction between Cisatracurium and Doxepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine train-of-four monitoring during anesthesia. Watch for anticholinergic effects such as tachycardia or urinary retention postoperatively.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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