Drug interactions
Cisatracurium + Doxycycline
Severity: Moderate
Cisatracurium and Doxycycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines have weak neuromuscular blocking properties and could modestly enhance blockade by cisatracurium. Clinical reports are limited and mostly involve other tetracyclines or parenteral use.
What this interaction means in plain words
Cisatracurium and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Doxycycline belongs to Anti Bacterial.
Why it happens
Possible additive neuromuscular blockade, potentially via calcium chelation and effects on neuromuscular transmission.
What to do
Monitor neuromuscular blockade with train-of-four during surgery and adjust cisatracurium dose. Confirm full recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisatracurium and Doxycycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cisatracurium
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Cisatracurium with Doxycycline?
MediHelp rates the interaction as moderate. Cisatracurium and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines have weak neuromuscular blocking properties and could modestly enhance blockade by cisatracurium. Clinical reports are limited and mostly involve other tetracyclines or parenteral use.
How serious is the interaction between Cisatracurium and Doxycycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four during surgery and adjust cisatracurium dose. Confirm full recovery before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
