Drug interactions
Cisatracurium + Magnesium
Severity: Moderate
Cisatracurium and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium sulfate enhances and prolongs the neuromuscular blockade of cisatracurium. Recovery may be delayed.
What this interaction means in plain words
Cisatracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Magnesium reduces acetylcholine release and postsynaptic sensitivity, adding to nondepolarizing blockade.
What to do
Use lower cisatracurium doses and monitor neuromuscular function with train-of-four.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Magnesium?
MediHelp rates the interaction as moderate. Cisatracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate enhances and prolongs the neuromuscular blockade of cisatracurium. Recovery may be delayed.
How serious is the interaction between Cisatracurium and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower cisatracurium doses and monitor neuromuscular function with train-of-four.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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