Drug interactions
Cisatracurium + Memantine-donepezil
Severity: Moderate
Cisatracurium and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors such as donepezil can oppose the effect of nondepolarizing neuromuscular blockers like cisatracurium. This may lead to a reduced or shortened blockade, and may complicate anesthetic management.
What this interaction means in plain words
Cisatracurium and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Donepezil increases acetylcholine at the neuromuscular junction, pharmacologically antagonizing competitive neuromuscular blockade.
What to do
Inform the anesthesia team of donepezil use before surgery and monitor neuromuscular function with a train-of-four monitor. Adjust the dose of cisatracurium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisatracurium and Memantine-donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Memantine-donepezil?
MediHelp rates the interaction as moderate. Cisatracurium and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors such as donepezil can oppose the effect of nondepolarizing neuromuscular blockers like cisatracurium. This may lead to a reduced or shortened blockade, and may complicate anesthetic management.
How serious is the interaction between Cisatracurium and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of donepezil use before surgery and monitor neuromuscular function with a train-of-four monitor. Adjust the dose of cisatracurium as needed.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
