Drug interactions
Cisatracurium + Neomycin
Severity: Moderate
Cisatracurium and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can potentiate and prolong non-depolarizing neuromuscular blockade, causing delayed recovery and respiratory depression. The risk with oral neomycin rises when it is absorbed through damaged bowel or in renal impairment.
What this interaction means in plain words
Cisatracurium and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Neomycin belongs to Anti Bacterial.
Why it happens
Aminoglycosides impair presynaptic acetylcholine release and postsynaptic sensitivity, adding to non-depolarizing blockade.
What to do
Monitor neuromuscular blockade with train-of-four and ensure ventilatory support is available through recovery. Lower the relaxant dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Neomycin?
MediHelp rates the interaction as moderate. Cisatracurium and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can potentiate and prolong non-depolarizing neuromuscular blockade, causing delayed recovery and respiratory depression. The risk with oral neomycin rises when it is absorbed through damaged bowel or in renal impairment.
How serious is the interaction between Cisatracurium and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and ensure ventilatory support is available through recovery. Lower the relaxant dose if needed.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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