Drug interactions
Cisatracurium + Nicardipine
Severity: Minor
Cisatracurium and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. Clinically this is usually small, but it may mean slower recovery from blockade in the perioperative setting.
What this interaction means in plain words
Cisatracurium and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Nicardipine belongs to Cardiovascular.
Why it happens
Calcium channel blockade may reduce prejunctional acetylcholine release and so add to postsynaptic nicotinic receptor blockade.
What to do
Monitor neuromuscular function with train-of-four during surgery and titrate cisatracurium to effect. Confirm adequate recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Nicardipine
Frequently asked questions
Can I take Cisatracurium with Nicardipine?
MediHelp rates the interaction as minor. Cisatracurium and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. Clinically this is usually small, but it may mean slower recovery from blockade in the perioperative setting.
How serious is the interaction between Cisatracurium and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during surgery and titrate cisatracurium to effect. Confirm adequate recovery before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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