Drug interactions
Cisatracurium + Oliceridine
Severity: Moderate
Cisatracurium and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid causing sedation and respiratory depression, which add to the effects of neuromuscular blockade in patients who are not ventilated. In ventilated patients the interaction is mainly relevant during emergence and weaning.
What this interaction means in plain words
Cisatracurium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from central opioid effects and peripheral paralysis from cisatracurium.
What to do
Use only with secured airway and mechanical ventilation, and use the lowest effective opioid dose. Confirm recovery of neuromuscular function and spontaneous ventilation before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Cisatracurium with Oliceridine?
MediHelp rates the interaction as moderate. Cisatracurium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid causing sedation and respiratory depression, which add to the effects of neuromuscular blockade in patients who are not ventilated. In ventilated patients the interaction is mainly relevant during emergence and weaning.
How serious is the interaction between Cisatracurium and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with secured airway and mechanical ventilation, and use the lowest effective opioid dose. Confirm recovery of neuromuscular function and spontaneous ventilation before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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