Drug interactions
Cisatracurium + Orphenadrin
Severity: Minor
Cisatracurium and Orphenadrin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisatracurium is a neuromuscular blocker used under anesthesia, and orphenadrine has weak neuromuscular effects as a skeletal muscle relaxant. Any added potentiation of blockade is expected to be small and is managed by the anesthesia team in a monitored setting.
What this interaction means in plain words
Cisatracurium and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Possible small additive skeletal muscle relaxation; the mechanism is not well established and the anticholinergic activity of orphenadrine does not meaningfully act at the nicotinic junction.
What to do
Monitor neuromuscular blockade with train-of-four during surgery and titrate cisatracurium to effect. Inform the anesthesia team of recent orphenadrine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisatracurium and Orphenadrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Orphenadrin
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Orphenadrin?
MediHelp rates the interaction as minor. Cisatracurium and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cisatracurium is a neuromuscular blocker used under anesthesia, and orphenadrine has weak neuromuscular effects as a skeletal muscle relaxant. Any added potentiation of blockade is expected to be small and is managed by the anesthesia team in a monitored setting.
How serious is the interaction between Cisatracurium and Orphenadrin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four during surgery and titrate cisatracurium to effect. Inform the anesthesia team of recent orphenadrine use.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
