Drug interactions
Cisatracurium + Prednisone
Severity: Moderate
Cisatracurium and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers, particularly in critically ill patients, are associated with acute quadriplegic myopathy. Prolonged weakness and delayed weaning from ventilation can result.
What this interaction means in plain words
Cisatracurium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Prednisone belongs to Endocrine.
Why it happens
Additive muscle injury, with steroids and prolonged neuromuscular blockade contributing to myosin loss and muscle denervation-like changes.
What to do
Use the lowest effective neuromuscular blocker dose for the shortest time and monitor depth of blockade with train-of-four. Assess for persistent weakness and consider creatine kinase measurement if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Prednisone?
MediHelp rates the interaction as moderate. Cisatracurium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers, particularly in critically ill patients, are associated with acute quadriplegic myopathy. Prolonged weakness and delayed weaning from ventilation can result.
How serious is the interaction between Cisatracurium and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective neuromuscular blocker dose for the shortest time and monitor depth of blockade with train-of-four. Assess for persistent weakness and consider creatine kinase measurement if suspected.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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