Drug interactions
Cisatracurium + Quinidine
Severity: Moderate
Cisatracurium and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine can potentiate nondepolarizing neuromuscular blockers and has been associated with recurrence of paralysis after recovery. Cisatracurium effects may therefore be prolonged or intensified.
What this interaction means in plain words
Cisatracurium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine has weak neuromuscular blocking activity and reduces acetylcholine release and postsynaptic sensitivity, adding to nondepolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four and reduce cisatracurium dosing as needed. Observe for recurrent weakness in the postoperative period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Cisatracurium with Quinidine?
MediHelp rates the interaction as moderate. Cisatracurium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine can potentiate nondepolarizing neuromuscular blockers and has been associated with recurrence of paralysis after recovery. Cisatracurium effects may therefore be prolonged or intensified.
How serious is the interaction between Cisatracurium and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce cisatracurium dosing as needed. Observe for recurrent weakness in the postoperative period.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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