Drug interactions
Cisplatin + Cyclophosphamide
Severity: Moderate
Cisplatin and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two cytotoxic drugs both suppress the bone marrow, so combined use increases the risk of neutropenia, anemia and thrombocytopenia. Cisplatin-induced renal impairment can also add to overall toxicity.
What this interaction means in plain words
Cisplatin and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Cyclophosphamide belongs to Oncology.
Why it happens
Additive myelosuppression, with possible added toxicity from cisplatin-related nephrotoxicity.
What to do
Monitor blood counts and renal function, and ensure hydration. Adjust doses or delay cycles for significant cytopenias or renal decline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Cyclophosphamide?
MediHelp rates the interaction as moderate. Cisplatin and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two cytotoxic drugs both suppress the bone marrow, so combined use increases the risk of neutropenia, anemia and thrombocytopenia. Cisplatin-induced renal impairment can also add to overall toxicity.
How serious is the interaction between Cisplatin and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, and ensure hydration. Adjust doses or delay cycles for significant cytopenias or renal decline.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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