Drug interactions
Cisplatin + Deflazacort
Severity: Moderate
Cisplatin and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin causes renal magnesium and potassium wasting, and deflazacort, a corticosteroid, can also lower serum potassium. Together they may produce clinically significant hypokalemia, with arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Cisplatin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Deflazacort belongs to Miscellaneous.
Why it happens
Additive potassium loss from cisplatin renal tubular toxicity and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium during therapy and replace as needed. Take extra care in patients on other QT-prolonging drugs or with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cisplatin with Deflazacort?
MediHelp rates the interaction as moderate. Cisplatin and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cisplatin causes renal magnesium and potassium wasting, and deflazacort, a corticosteroid, can also lower serum potassium. Together they may produce clinically significant hypokalemia, with arrhythmia risk in vulnerable patients.
How serious is the interaction between Cisplatin and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during therapy and replace as needed. Take extra care in patients on other QT-prolonging drugs or with heart disease.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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