Drug interactions
Cisplatin + Erdafitinib
Severity: Moderate
Cisplatin and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits OCT2, a renal transporter involved in cisplatin uptake into tubular cells and elimination. The effect on cisplatin exposure and toxicity is uncertain, with a possible change in nephrotoxicity.
What this interaction means in plain words
Cisplatin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits OCT2 and may alter renal handling of cisplatin.
What to do
Monitor renal function and electrolytes, and watch for cisplatin toxicity. Consider dose adjustment of cisplatin based on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Cisplatin with Erdafitinib?
MediHelp rates the interaction as moderate. Cisplatin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits OCT2, a renal transporter involved in cisplatin uptake into tubular cells and elimination. The effect on cisplatin exposure and toxicity is uncertain, with a possible change in nephrotoxicity.
How serious is the interaction between Cisplatin and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and electrolytes, and watch for cisplatin toxicity. Consider dose adjustment of cisplatin based on tolerability.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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