Drug interactions
Cisplatin + Foscarnet
Severity: Major
Cisplatin and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and cause magnesium, potassium and calcium wasting, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte disorders and cumulative toxicity.
What this interaction means in plain words
Cisplatin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive renal tubular toxicity and electrolyte wasting.
What to do
Avoid the combination where an alternative exists. If it is necessary, ensure vigorous hydration and monitor creatinine and electrolytes closely, with prompt replacement.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Foscarnet?
MediHelp rates the interaction as major. Cisplatin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and cause magnesium, potassium and calcium wasting, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte disorders and cumulative toxicity.
How serious is the interaction between Cisplatin and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it is necessary, ensure vigorous hydration and monitor creatinine and electrolytes closely, with prompt replacement.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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