Drug interactions
Cisplatin + Givinostat
Severity: Minor
Cisplatin and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin is taken up into renal tubular cells by OCT2, and givinostat has weak transporter inhibitory activity. Any effect on cisplatin exposure is probably small and largely theoretical.
What this interaction means in plain words
Cisplatin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisplatin belongs to Oncology; Givinostat belongs to Miscellaneous.
Why it happens
Possible weak inhibition of organic cation transporters affecting cisplatin handling; not clinically established.
What to do
No routine adjustment is needed; continue standard monitoring of renal function and blood counts during cisplatin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisplatin and Givinostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Cisplatin with Givinostat?
MediHelp rates the interaction as minor. Cisplatin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cisplatin is taken up into renal tubular cells by OCT2, and givinostat has weak transporter inhibitory activity. Any effect on cisplatin exposure is probably small and largely theoretical.
How serious is the interaction between Cisplatin and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; continue standard monitoring of renal function and blood counts during cisplatin therapy.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
