Drug interactions
Cisplatin + Ifosfamide
Severity: Major
Cisplatin and Ifosfamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and myelosuppressive, and combined use can increase renal tubular injury, neurotoxicity, ototoxicity and cytopenias. Prior cisplatin exposure may increase the risk of ifosfamide-associated kidney and nerve toxicity.
What this interaction means in plain words
Cisplatin and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive nephrotoxicity, neurotoxicity and myelosuppression.
What to do
Monitor renal function, electrolytes, hearing and blood counts, and ensure vigorous hydration. Reduce or withhold doses if renal function or neurological status deteriorates.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Ifosfamide?
MediHelp rates the interaction as major. Cisplatin and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and myelosuppressive, and combined use can increase renal tubular injury, neurotoxicity, ototoxicity and cytopenias. Prior cisplatin exposure may increase the risk of ifosfamide-associated kidney and nerve toxicity.
How serious is the interaction between Cisplatin and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, electrolytes, hearing and blood counts, and ensure vigorous hydration. Reduce or withhold doses if renal function or neurological status deteriorates.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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