Drug interactions
Cisplatin + Palifermin
Severity: Moderate
Cisplatin and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial proliferation, which may increase mucosal sensitivity to cytotoxic drugs. Given close to chemotherapy, it worsened oral mucositis severity and duration in trials of other regimens.
What this interaction means in plain words
Cisplatin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced epithelial proliferation increases susceptibility of mucosal cells to cytotoxic damage.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after cisplatin. Monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Palifermin
Frequently asked questions
Can I take Cisplatin with Palifermin?
MediHelp rates the interaction as moderate. Cisplatin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial proliferation, which may increase mucosal sensitivity to cytotoxic drugs. Given close to chemotherapy, it worsened oral mucositis severity and duration in trials of other regimens.
How serious is the interaction between Cisplatin and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after cisplatin. Monitor for mucositis.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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