Drug interactions
Cisplatin + Polymyxin b
Severity: Major
Cisplatin and Polymyxin b: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and polymyxin B is also neurotoxic, while cisplatin is ototoxic and neurotoxic. Combined use markedly raises the risk of acute kidney injury and neurologic toxicity.
What this interaction means in plain words
Cisplatin and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Polymyxin b belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and neurotoxicity through tubular injury.
What to do
Avoid concurrent use if possible; otherwise monitor serum creatinine, electrolytes and neurologic status and maintain hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Polymyxin b
- Cidofovir + Polymyxin b Contraindicated
- Colistin + Polymyxin b Contraindicated
- Acyclovir + Polymyxin b Major
- Adefovir + Polymyxin b Major
- Amikacin + Polymyxin b Major
- Amphotericin b + Polymyxin b Major
Frequently asked questions
Can I take Cisplatin with Polymyxin b?
MediHelp rates the interaction as major. Cisplatin and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and polymyxin B is also neurotoxic, while cisplatin is ototoxic and neurotoxic. Combined use markedly raises the risk of acute kidney injury and neurologic toxicity.
How serious is the interaction between Cisplatin and Polymyxin b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise monitor serum creatinine, electrolytes and neurologic status and maintain hydration.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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