Drug interactions
Cisplatin + Rituximab
Severity: Moderate
Cisplatin and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin is nephrotoxic, and renal toxicity has been reported when rituximab is given with it, notably in the setting of tumor lysis or infusion reactions. The combination can lead to worsening kidney function.
What this interaction means in plain words
Cisplatin and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Rituximab belongs to Musculoskeletal.
Why it happens
Additive renal injury: cisplatin tubular toxicity plus rituximab-associated tumor lysis or cytokine-release related kidney injury.
What to do
Ensure adequate hydration and monitor serum creatinine and electrolytes before and after each cycle. Adjust or hold cisplatin if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Rituximab?
MediHelp rates the interaction as moderate. Cisplatin and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cisplatin is nephrotoxic, and renal toxicity has been reported when rituximab is given with it, notably in the setting of tumor lysis or infusion reactions. The combination can lead to worsening kidney function.
How serious is the interaction between Cisplatin and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine and electrolytes before and after each cycle. Adjust or hold cisplatin if renal function worsens.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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