Drug interactions
Cisplatin + Streptomycin
Severity: Major
Cisplatin and Streptomycin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and ototoxic, and combined use markedly increases risk of kidney injury and permanent hearing loss.
What this interaction means in plain words
Cisplatin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity via tubular and cochlear cell injury.
What to do
Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and electrolytes and perform audiometry regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Cisplatin 1 mg/ml concentrate for solution for Infusion - SmPC sections 4.3/4.5 (class statement: aminoglycosides; "Concomitant administration of nephrotoxic (e.g. cephalosporins, aminoglycosides, amphotericin B or contrast media) medicinal products will potentiate the toxic ") — electronic medicines compendium (UK SmPC)
Other interactions of Streptomycin
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Streptomycin?
MediHelp rates the interaction as major. Cisplatin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and ototoxic, and combined use markedly increases risk of kidney injury and permanent hearing loss.
How serious is the interaction between Cisplatin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and electrolytes and perform audiometry regularly.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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