Drug interactions
Cisplatin + Tisagenlecleucel
Severity: Major
Cisplatin and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin is myelosuppressive and immunosuppressive and can impair the expansion and function of CAR T cells. Chemotherapy near the time of cell infusion may also increase infection risk.
What this interaction means in plain words
Cisplatin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Tisagenlecleucel belongs to Oncology.
Why it happens
Additive immunosuppression and cytotoxic effects on lymphocytes, potentially reducing CAR T-cell persistence and increasing infection risk.
What to do
Avoid cytotoxic chemotherapy in the period around leukapheresis and CAR T infusion except for planned lymphodepletion. Monitor for infection and cytopenias if chemotherapy is needed afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Cisplatin with Tisagenlecleucel?
MediHelp rates the interaction as major. Cisplatin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is myelosuppressive and immunosuppressive and can impair the expansion and function of CAR T cells. Chemotherapy near the time of cell infusion may also increase infection risk.
How serious is the interaction between Cisplatin and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cytotoxic chemotherapy in the period around leukapheresis and CAR T infusion except for planned lymphodepletion. Monitor for infection and cytopenias if chemotherapy is needed afterward.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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