Drug interactions
Cisplatin + Vinorelbine
Severity: Moderate
Cisplatin and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining cisplatin with vinorelbine increases the rate and severity of myelosuppression, particularly neutropenia. Additive neurotoxicity and ototoxicity or nephrotoxicity concerns may also arise.
What this interaction means in plain words
Cisplatin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicity, mainly overlapping bone marrow suppression.
What to do
Monitor neutrophil counts before each dose and reduce vinorelbine dose for neutropenia. Check renal function and neuropathy symptoms during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Cisplatin with Vinorelbine?
MediHelp rates the interaction as moderate. Cisplatin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining cisplatin with vinorelbine increases the rate and severity of myelosuppression, particularly neutropenia. Additive neurotoxicity and ototoxicity or nephrotoxicity concerns may also arise.
How serious is the interaction between Cisplatin and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts before each dose and reduce vinorelbine dose for neutropenia. Check renal function and neuropathy symptoms during therapy.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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