Drug interactions
Citalopram + Crofelemer
Severity: Minor
Citalopram and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer inhibits CYP3A4 in vitro at gut concentrations but is minimally absorbed, so a meaningful systemic effect on citalopram is unlikely. Clinical relevance is probably small.
What this interaction means in plain words
Citalopram and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Potential intestinal CYP3A4 inhibition by crofelemer, with negligible systemic exposure.
What to do
No routine adjustment is needed; be alert for increased citalopram adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Citalopram with Crofelemer?
MediHelp rates the interaction as minor. Citalopram and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer inhibits CYP3A4 in vitro at gut concentrations but is minimally absorbed, so a meaningful systemic effect on citalopram is unlikely. Clinical relevance is probably small.
How serious is the interaction between Citalopram and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be alert for increased citalopram adverse effects if symptoms arise.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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