Drug interactions
Citalopram + Fedratinib
Severity: Moderate
Citalopram and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2C19, CYP3A4 and CYP2D6, which can raise citalopram concentrations. Higher exposure increases dose-related effects such as QT prolongation.
What this interaction means in plain words
Citalopram and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP2C19 and CYP2D6 (and CYP3A4), reducing citalopram metabolism.
What to do
Monitor for citalopram adverse effects and consider a lower dose, staying within labeled maximums. Obtain an ECG if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Citalopram with Fedratinib?
MediHelp rates the interaction as moderate. Citalopram and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2C19, CYP3A4 and CYP2D6, which can raise citalopram concentrations. Higher exposure increases dose-related effects such as QT prolongation.
How serious is the interaction between Citalopram and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects and consider a lower dose, staying within labeled maximums. Obtain an ECG if QT risk factors are present.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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