Drug interactions
Citalopram + Fenfluramine
Severity: Major
Citalopram and Fenfluramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine releases serotonin and with an SSRI may increase the risk of serotonin syndrome. Fenfluramine labeling advises caution with serotonergic agents.
What this interaction means in plain words
Citalopram and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects through serotonin release by fenfluramine and reuptake inhibition by citalopram.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability, particularly at initiation or dose increases. Discontinue one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Citalopram with Fenfluramine?
MediHelp rates the interaction as major. Citalopram and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenfluramine releases serotonin and with an SSRI may increase the risk of serotonin syndrome. Fenfluramine labeling advises caution with serotonergic agents.
How serious is the interaction between Citalopram and Fenfluramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability, particularly at initiation or dose increases. Discontinue one agent if serotonin syndrome is suspected.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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