Drug interactions
Fenfluramine + Linezolid
Severity: Contraindicated
Fenfluramine and Linezolid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release and linezolid inhibits MAO. Labeling prohibits MAOI use because of serotonin syndrome and hypertensive crisis risk.
What this interaction means in plain words
Fenfluramine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fenfluramine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effect from serotonin release plus MAO inhibition.
What to do
Do not coadminister. Use an alternative antibiotic and allow the washout period stated in labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
- Amitriptyline + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Linezolid?
MediHelp rates the interaction as contraindicated. Fenfluramine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fenfluramine increases serotonin release and linezolid inhibits MAO. Labeling prohibits MAOI use because of serotonin syndrome and hypertensive crisis risk.
How serious is the interaction between Fenfluramine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use an alternative antibiotic and allow the washout period stated in labeling.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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