Drug interactions
Fenfluramine + Isocarboxazid
Severity: Contraindicated
Fenfluramine and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release, so with an MAOI there is a risk of serotonin syndrome and hypertensive reactions. Use is prohibited within 14 days of an MAOI.
What this interaction means in plain words
Fenfluramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fenfluramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition blocks serotonin breakdown while fenfluramine promotes serotonin release and blocks reuptake.
What to do
Do not coadminister, and do not start fenfluramine within 14 days of stopping isocarboxazid. Select a different antiseizure therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenfluramine and Isocarboxazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
- Amitriptyline + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Fenfluramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fenfluramine increases serotonin release, so with an MAOI there is a risk of serotonin syndrome and hypertensive reactions. Use is prohibited within 14 days of an MAOI.
How serious is the interaction between Fenfluramine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister, and do not start fenfluramine within 14 days of stopping isocarboxazid. Select a different antiseizure therapy.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
