Drug interactions
Fenfluramine + Selegiline
Severity: Contraindicated
Fenfluramine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is contraindicated with MAO inhibitors because serotonin accumulation can cause serotonin syndrome. Hypertensive reactions are also possible.
What this interaction means in plain words
Fenfluramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fenfluramine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Fenfluramine increases synaptic serotonin release and MAO inhibition blocks serotonin degradation, producing additive serotonergic toxicity.
What to do
Do not use together; wait at least 14 days after stopping an MAO inhibitor before starting fenfluramine, and 14 days after stopping fenfluramine before an MAO inhibitor.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
- Amitriptyline + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Selegiline?
MediHelp rates the interaction as contraindicated. Fenfluramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fenfluramine is contraindicated with MAO inhibitors because serotonin accumulation can cause serotonin syndrome. Hypertensive reactions are also possible.
How serious is the interaction between Fenfluramine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; wait at least 14 days after stopping an MAO inhibitor before starting fenfluramine, and 14 days after stopping fenfluramine before an MAO inhibitor.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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